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What are some of the abbreviations in results of the trials like CR, PR etc?

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What are some of the abbreviations in results of the trials like CR, PR etc?

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List of some of them

ORR – overall response rate

CR – complete response – Disappearance of all target lesions

PR – partial response - At least a 30% decrease in the sum of the LD of target lesions, taking as reference the baseline sum LD

SD - Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum LD since the treatment started

Progressive Disease (PD): At least a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD (longest diameter) recorded since the treatment started or the appearance of one or more new lesions

Evaluation of non-target lesions

Complete Response (CR): Disappearance of all non-target lesions and normalization of tumor marker level

Incomplete Response/Stable Disease (SD): Persistence of one or more non-target lesion(s) or/and maintenance of tumor marker level above the normal limits

Progressive Disease (PD): Appearance of one or more new lesions and/or unequivocal progression of existing non-target lesions

AE -adverse events

PK – pharmacokinetic - the characteristic interactions of a drug and the body in terms of its absorption, distribution, metabolism, and excretion

PD- Pharmacodynamics, on the other hand, is defined as the study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of their actions and effects with their chemical structure. It is the study of the effects of substances or drugs to the body

BID -bis in die (twice a day)

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